Cellular Senescence:Ex Vivop53-Dependent Asymmetric Cell Kinetics

Cellular senescence: ex vivo p53-dependent asymmetric cell kinetics

Although senescence is a defining property of euploid mammalian cells, its physiologic basis remains obscure. Previously, cell kinetics properties of normal tissue cells have not been considered in models for senescence. We now provide evidence that senescence is in fact the natural consequence of normal in vivo somatic stem cell kinetics extended in culture. This concept of senescence is based...

Investigation of Growth Factors and Cytokines that Suppress Adult Stem Cell Asymmetric Cell Kinetics

Adult stem cells are potentially useful in many biomedical applications that can save lives and increase the quality of a patient's life, such as tissue engineering, cell replacement, and gene therapy. However, these applications are limited because of the difficulty in isolating and expanding pure populations of adult stem cells (ASCs). A major barrier to ASC expansion in vitro is their proper...

Simple formula for asymmetric Marcus–Hush kinetics

The Marcus–Hush theory of electron transfer has seen increasing use as a predictive alternative to the phenomenological Butler–Volmer (BV) equation for Faradaic reactions kinetics. Here, we analyze and simplify the asymmetric Marcus–Hush (AMH) model, first proposed by Marcus and recently used by Compton’s group to fit experimental data that exhibit two different reorganization energies, dependi...

Asymmetric melting and freezing kinetics in silicon.

Cellular Kinetics in Acute Leukemia

In most patients with acute leukemia, the generation time of leukemic cells is about (10 hours, longer than for normal cells. Approximate times for the phases of the cell cycle are: DNA synthesis (S), 20 hours; mitosis (M), 2 hours; and the post-synthesis and postmitosis rest phases (G2 and Gi), 2 and 36 hours, respectively. A most important finding has been that a variable proportion of leukem...